Department of Biochemical Sciences and Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Italy. CNR Institute of Molecular Biology and Pathology, 00185 Rome, Italy. Faculty of Pharmacy and Biochemistry, University of Zagreb, 10000 Zagreb, Croatia. Department of Clinical and Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy. Centre for Experimental Neurological Therapies, S. Andrea Hospital-Site, Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome, 00185 Rome, Italy.